Efficacy of Porous Bovine Bone Mineral in Various Types of Osseous Deficiencies: Clinical Observations and Literature Review


1. Kent JN, Quinn JH, Zide MF, Finger IM, Jarcho M, Rothstein SS. Correction of alveolar ridge deficiencies with non-resorbable hydroxylapatite. J Am Dent Assoc 1982;105:993–1001.

2. Scheer P, Boyne PJ. Maintenance of alveolar bone through implantation of bone graft substitutes in tooth extraction sockets. J Am Dent Assoc 1987;114:594–597.

3. Bahat O, Deeb C, Golden T, Komamyckyj O. Preservation of ridges utilizing hydroxyapatite. Int J Periodontics Restorative Dent 1987;7(6):35–41.

4. Wilson J, Clark AE, Hall M, Hench LL. Tissue response to Bioglass endosseous ridge maintenance implants. J Oral Implantol 1993;19:295–302.

5. Gross J. Ridge preservation using HTR synthetic bone following tooth extraction. Gen Dent 1995;43:364–367.

6. Boyne PJ. Use of HTR in tooth extraction sockets to maintain alveolar ridge height. Gen Dent 1995;43:470–473.

7. Piattelli A, Podda G, Scarano A. Clinical and histological results in alveolar ridge enlargement using coralline calcium carbonate. Biomaterials 1997;18:623–627.

8. Becker W, Urist M, Becker BE, et al. Clinical and histological observations of sites implanted with intraoral autologous bone grafts or allografts. 15 human case reports. J Periodontol 1996;67:1025–1033.

9. Nevins M, Mellonig JT. Enhancement of the damaged edentulous ridge to receive dental implants: A combination of allograft and the Gore-Tex membrane. Int J Periodontics Restorative Dent 1992;12:96–111.

10. Simion M, Dahlin C, Trisi P, Piattelli A. Qualitative and quantitative comparative study on different filling materials used in bone tissue regeneration: A controlled clinical study. Int J Periodontics Restorative Dent 1994;14:198–215.

11. Boyne PJ. Bone grafts: Materials. In: Evensen L (ed). Osseous Reconstruction of the Maxilla and the Mandible. Chicago: Quintessence, 1997:3–11.

12. Becker W, Lynch SE, Lekholm U, et al. A comparison of e-PTFE membranes alone or in combination with platelet derived growth factors and insulin like growth factor-J or DFDB in promoting bone formation around immediate extraction socket implants. J Periodontol 1992;63:929–940.

13. Becker W, Urist MR, Tucker LM, Becker BE, Ochsenbein C. Human demineralized freeze-dried bone: Inadequate induced bone formation in athymic mice. A preliminary report. J Periodontol 1995;66:822–828.

14. Becker W, Becker BE, Caffesse R. A comparison of DFDB and autologous bone to induce bone formation in human extraction sockets. J Periodontol 1994;65:1128–1133.

15. Schwartz Z, Mellonig JT, Carnes DL Jr, et al. Ability of commercial demineralized freeze-dried bone allograft to induce new bone formation. J Periodontol 1996;67:918–926.

16. Boyne PJ. Treatment of oral bony defects in man with anorganic heterogeneous bone. Oral Surg Oral Med Oral Pathol 1958;11:322–329.

17. Boyne PJ, Losee FL. The use of anorganic bone implants in oral surgery. J Oral Surg 1958;16:53–63.

18. Mandelkow HK, Hallfeldt KK, Kessler SB, Gayk M, Siebeck M, Schweiberer L. New bone formation following implantation of various hydroxyapatite ceramics. Animal experiment with bore hole models of the sheep tibia. Unfallchirurg 1990;93:376–379.

19. Pinholt EM, Bang G, Haanaes HR. Alveolar ridge augmentation in rats by Bio-Oss. Scand J Dent Res 1991;99:154–161.

20. Pinholt EM, Ruyter IE, Haanaes HR, Bang G. Chemical, physical, and histologic studies on four commercial apatites used for alveolar ridge augmentation. J Oral Maxillofac Surg 1992;50:859–867.

21. Klinge B, Alberius P, Isaksson S, Jonsson J. Osseous response to implanted natural bone mineral and synthetic hydroxylapatite ceramics in the repair of experimental skull bone defects. J Oral Maxillofac Surg 1992;50:241–249.

22. Isaksson S. Aspects of bone healing and bone substitute incorporation. An experimental study in rabbit skull bone defects. Swed Dent J 1992;84(suppl):1–46.

23. Fukuta K, Har-Shai Y, Collares MV, Lichten JB, Jackson IT. Comparison of inorganic bovine bone mineral particles with porous hydroxyapatite granules and cranial bone dust in the reconstruction of full thickness skull defect. J Craniofac Surg 1992;3:25–29.

24. Thaller SR, Hoyt J, Borjeson K, Dart P, Tesluk H. Reconstruction of calvarial defects with anorganic barrier bone mineral in a rabbit model. J Craniofac Surg 1993;4:79–84.

25. Callan DP, Rohrer MD. Use of bovine-derived hydroxyapatite in the treatment of edentulous ridge defects: A human clinical and histologic case report. J Periodontol 1993;64:575–582.

26. Hislop WS, Finlay PM, Moos KF. A preliminary study into the uses of anorganic bovine bone in oral and maxillofacial surgery. Br J Oral Maxillofac Surg 1993;31:149–153.

27. Cohen RE, Mullarky RH, Noble B, Comeau RL, Neiders ME. Phenotypic characterization of mononuclear cells following anorganic bovine bone implantation in situ. J Periodontol 1994;65:1008–1015.

28. Spector M. Anorganic bovine bone and ceramic analogs of bone mineral as implants to facilitate bone regeneration. Clin Plast Surg 1994;21:437–444.

29. Stassen LFA, Hislop WS, Still DM, Moos KF. Use of anorganic bone in periapical defects following apical surgery--A prospective trial. Br J Oral Maxillofac Surg 1994;32:83–88.

30. Jensen SS, Aaboe M, Pinholt EM, Hjørting-Hansen E, Melsen F, Ruyter IE. Tissue reaction and material characteristics of four bone substitutes. Int J Oral Maxillofac Implants 1996;11:55–66.

31. Dies F, Etienne D, Bou Abboud N, Ouhayoun JP. Bone regeneration in extraction sites after immediate placement of an e-PTFE membrane with or without a biomaterial. Report on 12 consecutive cases. Clin Oral Implants Res 1996;7:277–285.

32. Zitzmann NU, Naef R, Schärer P. Resorbable versus non-resorbable membranes in combination with Bio-Oss for guided bone regeneration. Int J Oral Maxillofac Implants 1997;12:844–852.

33. Camelo M, Nevins ML, Schenk RK, et al. Clinical, radiographic, and histologic evaluation of human periodontal defects treated with Bio-Oss and Bio-Gide. Int J Periodontics Restorative Dent 1998;18:321–333.

34. Clergeau LP, Danan M, Clergeau-Guerithault S, Brion M. Healing response to anorganic bone implantation in periodontal intrabony defects in dogs. Part I. Bone regeneration. A microradiographic study. J Periodontol 1996;67:140–149.

35. Hoshaw SJ, Brunski JB, Cochran GVB. Mechanical loading of Brånemark implants affects interfacial bone modeling and remodeling. Int J Oral Maxillofac Implants 1994;9:345–360.

36. Misch CE. Progressive bone loading. In: Contemporary Implant Dentistry. St Louis: Mosby, 1999:595–608.

37. Dahlin C, Linde A, Gottlow J, Nyman S. Healing of bone defects by guided tissue regeneration. Plast Reconstr Surg 1988;81:672–676.

38. Artzi Z, Nemcovsky C. The application of deproteinized bovine bone mineral for ridge presentation prior to implantation. Clinical and histological observations in a case report. J Periodontol 1998;69:1062–1067.

39. Dahlin C, Andersson L, Linde A. Bone augmentation at fenestrated implants by an osteopromotive membrane technique. A controlled clinical study. Clin Oral Implants Res 1991;2:159–165.

40. Jovanovic SA, Spiekermann H, Richter EJ. Bone regeneration on titanium dental implants with dehisced defect sites. A clinical study. Int J Oral Maxillofac Implants 1992;7:233–245.

41. Boyne PJ, James RA. Grafting of the maxillary sinus floor with autogenous marrow and bone. J Oral Surg 1980;38:613–616.

42. Tatum H Jr. Maxillary and sinus implant reconstruction. Dent Clin North Am 1986;30:201–229.

43. Summers RB. A new concept in maxillary implant surgery: The osteotome technique. Compend Contin Educ Dent 1994;15:152–161.

44. Summers RB. The osteotome technique. Part 3. Less invasive methods of elevating the sinus floor. Compend Contin Educ Dent 1994;15:698–708.

45. Summers RB. The osteotome technique. Part 4. Future site development. Compend Contin Educ Dent 1995;16:1090–1098.

46. Jemt T, Lekholm U. Implant treatment in edentulous maxillae: A 5-year follow-up report on patients with different degrees of jaw resorption. Int J Oral Maxillofac Implants 1995;10:303–311.

47. Block MS, Gardiner D, Kent JN, Misiek DJ, Finger IM, Guerra L. Hydroxyapatite coated cylindrical implants in the posterior mandible: 10 year observations. Int J Oral Maxillofac Implants 1996;11:626–633.

48. Urist MR, Nilsson O, Rasmussen J, et al. Bone regeneration under the influence of a bone morphogenetic protein (BMP) beta tricalcium phosphate (TCP) composite in skull trephine defects in dogs. Clin Orthop Rel Res 1987;214:295–304.

49. Sampath TK, Özkaynak E, Jones WK, et al. Recombinant human osteogenic protein (hOP-1) induces new bone formation with a specific activity comparable to that of natural bovine osteogenic protein. J Bone Miner Res 1991;6(suppl):155.

50. Toriumi DM, Kotler HS, Luxenberg DP, Holtrop ME, Wang EA. Mandibular reconstruction with a recombinant bone-inducing factor: Functional, histologic, and biomechanical evaluation. Arch Otolaryngol Head Neck Surg 1991;117:1101–1112.

51. Boyne PJ. Reconstruction of discontinuity mandibular defects in rhesus monkeys using rhBMP-2. J Oral Maxillofac Surg 1995;53(suppl 4):92.

52. Sigurdsson TJ, Lee MB, Kubota K, Turek TJ, Wozney JM, Wikesjö UME. Periodontal repair in dogs: Recombinant human bone morphogenetic protein-2 significantly enhances periodontal regeneration. J Periodontol 1995;66:131–138.

53. Nevins M, Kirker-Head C, Nevins M, Wozney JM, Palmer P, Graham D. Bone formation in the goat maxillary sinus induced by absorbable collagen sponge implants impregnated with recombinant human bone morphogenetic protein-2. Int J Periodontics Restorative Dent 1996;16:8–19.

54. Marden LJ, Hollinger JO, Chaudhari A, Turek T, Schaub RG, Ron E. Recombinant human bone morphogenetic protein-2 is superior to demineralized bone matrix in repairing craniotomy defects in rats. J Biomed Mater Res 1994;28:1127–1138.

55. Boyne PJ, Marx RE, Nevins M, et al. A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation. Int J Periodontics Restorative Dent 1997;17:11–25.

56. Lee MB. Bone morphogenic protein background and implications for oral reconstruction. A review. J Clin Periodontol 1997;24:355–365.

57. Holmes RE, Hagler HK. Porous hydroxyapatite as a bone graft substitute in cranial reconstruction: A histometric study. Plast Reconstr Surg 1988;81:662–671.

58. Hupp JR, McKenna SJ. Use of porous hydroxylapatite blocks for augmentation of atrophic mandibles. J Oral Maxillofac Surg 1988;46:538–545.

59. Holmes RE, Wardrop RW, Wolford LM. Hydroxylapatite as a bone graft substitute in orthognathic surgery: Histologic and histometric findings. J Oral Maxillofac Surg 1988;46:661–671.

60. Pinholt EM, Haanaes HR, Roervik M, Donath K, Bang G. Alveolar ridge augmentation by osteoinductive materials in goats. Scand J Dent Res 1992;100:361–365.

61. Urist MR. Bone: Formation by autoinduction. Science 1965;150:893–899.

62. Harakas N. Demineralized bone matrix induced osteogenesis. Clin Orthop 1984;188:239–251.

63. Reddi AH, Wientroub S, Mathukmuaran N. Biologic principles of bone induction. Orthop Clin North Am 1987;18:207–212.

64. Tomford WW. Transmission of disease through transplantation of musculoskeletal allografts. J Bone Joint Surg Am 1995;77:1742–1754.

65. Artzi Z. Coronal ridge augmentation in absence of bilateral bony plates around a pathologically denuded implant surface. Int J Periodontics Restorative Dent 2000;20:191–197.

66. Hämmerle CHF, Olah AJ, Schmid J, et al. The biological effect of natural bone mineral on bone neoformation on the rabbit skull. Clin Oral Implants Res 1997;8:198–207.

67. Berglundh T, Lindhe J. Healing around implants placed in bone defects treated with Bio Oss. Clin Oral Implants Res 1997;8:117–124.

68. Wozney JM. The bone morphogenetic protein family and osteogenesis. Mol Reprod Dev 1992;32:160–167.

69. Skoglund A, Hising P, Young C. A clinical and histologic examination in humans of the osseous response to implanted natural bone mineral. Int J Oral Maxillofac Implants 1997;12:194–199.

70. Schmid J, Hämmerle CHF, Olah AJ, Lang NP. Membrane permeability is unnecessary for guided generation of new bone. Clin Oral Implants Res 1994;5:125–130.

71. Buser D, Dula K, Belser U, Hirt HP, Berthold H. Localized ridge augmentation using guided bone regeneration. 1. Surgical procedure in the maxilla. Int J Periodontics Restorative Dent 1993;13:29–45.

72. Nevins M, Mellonig JT. The advantages of localized ridge augmentation prior to implant placement: A staged event. Int J Periodontics Restorative Dent 1994;14:96–111.

73. Evian CI, Rosenberg ES, Coslet JG, Corn H. The osteogenic activity of bone removed from healing extraction sockets in humans. J Periodontol 1982;53:81–85.

74. Sobolik CF. Alveolar bone resorption. J Prosthet Dent 1960;10:612–619.

75. Carlsson GE, Bergman B, Hedegard B. Changes in contour of the maxillary alveolar process under immediate dentures. Acta Odontol Scand 1967;25:45–75.

76. Atwood DA. Some clinical factors related to rate of resorption of residual ridges. J Prosthet Dent 1962;12:441–450.

77. Pietrekovski J. The bony residual ridge in man. J Prosthet Dent 1975;34:456–462.

78. Tong DC, Rioux K, Drangsholt M, Beirne OR. A review of survival rates for implants placed in grafted maxillary sinuses using meta-analysis. Int J Oral Maxillofac Implants 1998;13:175–182.

79. Regev E, Smith RA, Perrott DH, Pogrel MA. Maxillary sinus complications related to endosseous implants. Int J Oral Maxillofac Implants 1995;10:451–461.

80. Smiler DG, Holmes RE. Sinus lift procedure using porous hydroxyapatite: A preliminary report. J Oral Implantol 1987;13:239–253.

81. Whittaker JM, James RA, Lozada J. Histological response and clinical evaluation of heterograft and allograft materials in the elevation of the maxillary sinus for the preparation of endosteal dental implant sites. Simultaneous sinus elevation and root for implantation: An eight month autopsy report. J Oral Implantol 1989;15:141–144.

82. Wagner JR. A 3-year clinical evaluation of resorbable hydroxylapatite osteogen used for sinus augmentation in conjunction with the insertion of endosseous implants. J Oral Implantol 1991;17:152–164.

83. Moy PK, Lundgren S, Holmes RE. Maxillary sinus augmentation: Histomorphometric analysis of graft materials for maxillary sinus floor augmentation. J Oral Maxillofac Surg 1993;51:857–862.

84. Wetzel AC, Stich A, Caffesse RG. Bone apposition onto oral implants in the sinus area filled with different grafting materials. A histological study in beagle dogs. Clin Oral Implants Res 1995;6:155–163.

85. Wheeler SL. Sinus augmentation for dental implants: The use of alloplastic materials. J Oral Maxillofac Surg 1997;55:1287–1293.

86. Valentini P, Abensur D, Densari D, Graziani JN, Hämmerle CHF. Histological evaluation of Bio-Oss in a 2-stage sinus floor elevation and implantation procedure. Clin Oral Implants Res 1998;9:59–64.

87. Froum SJ, Tarnow DP, Wallace SS, Rohrer MD, Cho SC. Sinus floor elevation using anorganic bovine bone matrix (OsteoGraf/N) with and without autogenous bone. A clinical, histologic, radiographic, and histomorphometric analysis--Part 2 of an ongoing prospective study. Int J Periodontics Restorative Dent 1998;18:529–543.

88. Haas R, Donath K, Fodinger M, Watzek G. Bovine hydroxyapatite for maxillary sinus grafting: Comparative histomorphometric findings in sheep. Clin Oral Implants Res 1998;9:107–116.

89. McAllister BS, Margolin MD, Cogan AG, Taylor M, Wollins J. Residual lateral wall defects following sinus grafting with recombinant human osteogenic protein-1 or Bio-Oss in the chimpanzee. Int J Periodontics Restorative Dent 1998;18:227–239.

90. Tataryn RW, Torabinejad M, Boyne PJ. Healing potential of osteotomies of the nasal sinus in the dog. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;84:196–202.