Aim: To show how to prepare a virtual set-up from digital casts, which can replace the plaster set-up. Using the virtual set-up, many solutions can be tried by the clinician and shared with the dentist, then presented to the patient. Material and Methods: Starting from digital casts, a virtual occlusal set-up in 3 dimensions can be performed with specific software. A format with all instructions and the impressions is sent via Internet, and, after few days, a file is returned, also via Internet, with the first set-up. From that point, all modifications can be made by the clinician, following a step-by-step procedure, and new set-ups can be made from that first solution. Results: Two cases of virtual occlusal set-up are presented; both are in the permanent dentition, without extractions. Prior to orthodontic treatment, the clinician can forecast the final result to determine the treatment plan, according to the amount and the direction of tooth movement. Conclusion: The virtual occlusal set-up can be used only in the permanent dentition, in malocclusions with an evident dentoalveolar problem in the 3 dimensions of space. It can also be used in preprosthetic dentistry. World J Orthod 2003;4:162–166.