This is a case report of a female, 33 years of age, with multiple missing posterior teeth in both arches, in addition to several diastemas in the anterior segment, with an edge-to-edge anterior relationship. Periodontal evaluation revealed generalized marginal gingivitis, 4 mm of marginal bone loss (type III) mesial to the mandibular central incisors, and gingival retraction in the labial, distal, and lingual aspects of both teeth. Periodontal treatment was performed prior to comprehensive orthodontic treatment and periodic control was maintained during active treatment. Orthodontic therapy concentrated on closing the diastemas between the mandibular central incisors using a segmented drop-loop (statically determinate system) to achieve maximum force and moment control. During the space closure in the mandibular arch, maxillary diastemas were also closed. The anterior relationship and esthetics improved dramatically. World J Orthod 2003;4:31–35.