Management of missing lateral incisors requires thorough treatment planning and an interdisciplinary approach. Occlusion and alignment are significant considerations. Three treatment options are available for replacing missing lateral incisors: canine substitution, tooth-supported restorations, and single-tooth implants. The ideal treatment is the one that satisfies the esthetic and functional requirements of the patient. The pros and cons of the various treatment options must be meticulously analyzed before arriving at a decision. This article closely examines patient selection and illustrates the importance of interdisciplinary treatment planning in an adult treated with canine substitution and orthognathic surgery. ORTHODONTICS (CHIC) 2012;13:e208–e219.

Key words: canine substitution, orthognathic surgery, skeletal Class III malocclusion