Langerhans cell histiocytosis is an uncommon disease that includes a spectrum of disorders in which there is an abnormal proliferation of Langerhans cells. This article describes a case of a benign form of multifocal Langerhans cell histiocytosis of the maxilla and mandible. The patient was followed for a period of 2 1/2 years, during which time there was spontaneous remission of some of the lesions.