The interdental pailla is the anatomic site most susceptible to periodontal disease. The gingival epithelium plays an important role as a barrier to protect the underlying connective tissue from exogenous noxious agents. A study was undertaken to evaluate the papillary epithelial response to reconstructive stresses conducted by gingival brushing (oral therapy) and scaling and root planing, intended to induce a keratinization associated with reduction or resolution of connective tissue inflammation. Results showed that patients who prolonged the interproximal hygiene practices for more than 30 minutes a day achieved a satisfactory keratinization of the papillary gingival epithelium.