Objective: To determine the impact of periodontal disease on quality of life using the Oral Health Impact Profile (OHIP) 14, simplified version. Method and Materials: A cross-sectional study was conducted involving a convenience sample of 401 patients of both sexes aged 19 to 71 years. After diagnoses of periodontal condition, the patients voluntarily completed a form to collect the OHIP-14, as well as socioeconomic and demographic data. Results: Chronic periodontitis was the most prevalent, affecting 227 patients (56.7%). With regard to the impact of periodontal disease on quality of life, functional limitation was the predominant item, affecting 91.5% of the sample. The patients with aggressive periodontitis achieved the highest impact scores. The highest scores on the OHIP-14 index were those of patients with a diagnosis of chronic or aggressive periodontitis. OHIP-14 scores were associated with sex, age, and income (P < .001). Conclusion: Functional limitation was the most affected dimension, and impact was significantly associated with age, income, and a diagnosis of periodontal disease. (Quintessence Int 2010;41:e111–e118)