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Quintessence Publishing: Journals: QI
Quintessence International

Edited by Eli Eliav

ISSN 0033-6572 (print) • ISSN 1936-7163 (online)

Publication:
October 1998
Volume 29 , Issue 10

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The biologic concept for the use of enamel matrix protein: True periodontal regeneration

Hirooka

Pages: 621-630
PMID: 9922759

Guided tissue regeneration procedures have been used successfully to reestablish periodontal attachment. However, this new attachment reportedly differs from the original attachment in strength and continuity. Enamel matrix proteins secreted by Hertwig’s epithelial sheath play an important role in cementogenesis on roots and in the d evelopment of the periodontal attachment apparatus. Enamel matrix protein harvested from developing porcine teeth, or enamel matrix derivative (Emdogain), is reported to induce true periodontal regeneration (the attachment of new, acellular cementum to the underlying dentin surface). The results of experimental and clinical trials of Emdogain are reviewed, and the procedure for application of the material is described.

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