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Quintessence Publishing: Journals: QI
Quintessence International

Edited by Eli Eliav

ISSN 0033-6572 (print) • ISSN 1936-7163 (online)

May 2008
Volume 39 , Issue 5

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Gingival crevicular fluid levels of aspartate aminotransferase and Alpha2-macroglobulin before and after topical application of metronidazole or scaling and root planing

Gerhild Knöfler, Dr Med1/Regina Purschwitz, Dr Med/Holger Jentsch, Prof Dr Med/Gerd Birkenmeier, Prof Dr Med/ Hannelore Schmidt, Prof Dr Med

Pages: 381–389
PMID: 19088952

Objective: The aim of this study was to compare the influence of topical metronidazole gel application and scaling and root planing on gingival crevicular fluid variables. Method and Materials: In a split-mouth study, 39 volunteers with chronic periodontitis were treated by metronidazole gel or scaling and root planing. Clinical attachment level and probing depth were recorded, and aspartate aminotransferase (AST) and total/transformed Alpha2-macroglobulin were determined in the gingival crevicular fluid at baseline, as well as after 3 and 6 months. Results: Both treatment procedures resulted in a gain of clinical attachment—0.67 mm for metronidazole and 0.50 mm for scaling and root planing (P < .001)—at the end of the study. The median probing depth was significantly reduced by 0.66 mm for metronidazole and 1.00 mm for scaling and root planing (P < .001) after 6 months. No change of AST was found. Alpha2-macroglobulin was significantly reduced for scaling and root planing and metronidazole after 3 and 6 months (P < .001). No significant difference was found between the 2 procedures at any variable. Conclusions: These data suggest that Alpha2-macroglobulin reflects clinical changes better than AST and that metronidazole and scaling and root planing have the same influence on clinical outcome and biochemical variables in the gingival crevicular fluid. (Quintessence Int 2008;39:381–389)

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