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Quintessence Publishing: Journals: QI
Quintessence International

Edited by Eli Eliav

ISSN 0033-6572 (print) • ISSN 1936-7163 (online)

April 2008
Volume 39 , Issue 4

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Relationship between interleukin-1 genotype and peri-implantitis: A literature review

Marina Andreiotelli, DDS, Dr Med Dent/Spiridon-Oumvertos Koutayas, DDS, Dr Med Dent, CDT/Phoebus N. Madianos, DDS, PhD/Jörg-Rudolf Strub, DDS, Dr med dent, PhD

Pages: 289–298
PMID: 19081897

Endosseous implants present high survival rates within a 10-year observation time; however, implant failure and biologic complications are not completely avoidable. Although specific bacteria, dental plaque, and environmental factors are associated with peri-implant disease, there are currently no reliable predictors of peri-implantitis occurrence and severity. Disagreement about which clinical measures of peri-implant health are of diagnostic value continues because of the complexity of the disease process. Thus, identification of genes that control or modify aspects of the host response may provide a method to identify individuals at an elevated risk for peri-implant infections. Elevated levels of the inflammatory cytokine interleukin-1 (IL-1) in the crevicular fluid around diseased implants seem to play an important role in the pathogenesis and severity of peri-implantitis. The purpose of this review article was to critically address the genetic associations regarding IL-1 genotype claimed for peri-implant disease and to validate the use of IL-1 genetic susceptibility tests. It was revealed that the diagnostic value of both IL-1 genotyping and genetic tests for peri-implantitis should be reconsidered before altering treatment planning, regimens, and maintenance in implant dentistry. (Quintessence Int 2008;39:289–298)

Key words: genotype, host response, interleukin-1, peri-implantitis, susceptibility

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