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Quintessence Publishing: Journals: QI
Quintessence International

Edited by Eli Eliav

ISSN 0033-6572 (print) • ISSN 1936-7163 (online)

November/December 2007
Volume 38 , Issue 10

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Effects of hemostatic agents on the histomorphologic response of human dental pulp capped with calcium hydroxide

Maria de Lourdes Rodrigues Accorinte, DDS, MS, PhDAlessandro D. Loguercio, DDS, MS, PhD/Alessandra Reis, DDS, PhD/Robert Holland, DDS, PhD

Pages: 843852
PMID: 18197324

Objective: To evaluate the response of human pulps capped with a calcium hydroxide [Ca(OH)2] cement after bleeding control with 2 hemostatic agents. Method and Materials: Pulps were exposed on the occlusal floor, and the bleeding was controlled either with saline solution (SS) or 2.5% sodium hypochlorite (NaOCl) (SH). After that, the pulp was capped with Ca(OH)2 cement and restored with resin composite. After 30 (groups SS30 and SH30) and 60 (groups SS60 and SH60) days, the teeth were extracted and processed with hematoxylin-eosin and categorized in a histologic score system. The data were subjected to Kruskal-Wallis and Mann-Whitney tests (a = .05). Results: Regarding dentin bridge formation, an inferior response of SH60 group was observed when compared to SS60 (P < .05). The response of the SH30 group generally was similar to that of the groups treated with saline solution. However, after 60 days, 2.5% NaOCl showed a trend toward having an inferior response. Conclusion: Using saline solution as a hemostatic agent before pulp capping with Ca(OH)2 resulted in a significantly better histomorphologic response than using 2.5% NaOCl as a hemostatic agent before capping with Ca(OH)2. (Quintessence Int 2007;38:843852)

Key words: biocompatibility, calcium hydroxide, hemostatic agents, human pulp, pulp therapy, saline solution, sodium hypochlorite

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