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Quintessence Publishing: Journals: QI
Quintessence International

Edited by Eli Eliav

ISSN 0033-6572 (print) • ISSN 1936-7163 (online)

November 2005
Volume 36 , Issue 10

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Principles and mechanisms of peri-implant soft tissue healing

Stefan Schultze-Mosgau, PhD, DMD, Dr Med, Dr Med Dent/Markus B. Blatz, DMD, Dr Med Dent/Falk Wehrhan, DMD, Dr Med, Dr Med Dent/Karl Andreas Schlegel, PhD, DMD, Dr Med, Dr Med Dent/Michael Thorwart, DMD, Dr Med, Dr Med Dent/Stefan Holst, DMD, Dr Med Dent

Pages: 759769
PMID: 16261792

The long-term clinical and esthetic success of implant-supported restorations is determined by osseointegration and optimal remodeling of peri-implant soft tissues. Complications of soft-tissue management are often caused by fibrotic regeneration of oral mucosa after multiple surgical procedures. Knowledge of the proliferative processes in wound healing is necessary to attain adequate soft-tissue conditions. Successful reconstruction of peri-implant soft tissues is feasible even in fibrotic conditions when appropriate surgical techniques are selected. The pleiotropic proliferative cytokine TGF-b is involved in the regulation of all phases of wound healing and tissue remodeling. The isoform TGF-b1 is a cytokine associated with the development of fibrotic tissue. Overexpression of TGF-b1 causes scarring and fibrosis, and results in limited clinical success of intraoral soft-tissue management. Experimental therapeutic approaches with neutralizing antibodies to block TGF-b1 resulted in less scarring and a reduction of fibrosis. Further molecular biologic research of cell-matrix-cytokine interactions in wound healing will provide highly specific antifibrotic therapeutic approaches in the future. (Quintessence Int 2005;36:759769)
Key words: fibrosis, implants, soft tissue, transforming growth factor-beta, wound healing

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