Objective: The influence of menopause on vascular inflammation
and systemic bone loss has been documented. The
purpose of this cross-sectional study was to assess the periodontal
status, high-sensitivity C-reactive protein (HsCRP)
level, and estrogen level in women with early menopause and
women with normal menopause. Method and Materials: A
total of 103 participants comprising normal menopausal
women (n = 53) and early menopausal women (n = 50) were
examined. Periodontal parameters, anthropometric parameters,
and metabolic parameters including serum levels of
HsCRP and estrogen were recorded. Results: Women with
early menopause (age 49.02 ± 2.70 years, postmenopausal
period 5.86 ± 2.48 years) had higher clinical attachment loss
(CAL) and HsCRP along with increased sites with bleeding on probing (BOP) as compared with normal menopausal women
(age 50.56 ± 1.94 years; postmenopausal period 2.03 ± 1.15).
On partial correlation analysis after controlling for age, Plaque
Index (PI), and body mass index (BMI), CAL correlated positively
and significantly with HsCRP and duration of menopause
(P = .000), and negatively with estradiol in pooled data.
Multivariate linear regression analysis revealed that CAL
(dependent variable) has significant association with HsCRP
(P = .000, r2 = .343) and duration of menopause (P = .001,
r2 = .343). Estrogen status also correlated with HsCRP.
Conclusion: CAL and HsCRP were higher in women with
early menopause. CAL was significantly correlated with postmenopausal
period and HsCRP in the population studied.