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Quintessence Publishing: Journals: QI
Quintessence International

Edited by Eli Eliav

ISSN 0033-6572 (print) • ISSN 1936-7163 (online)

November/December 2014
Volume 45 , Issue 10

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Mandible reconstruction using rhBMP-2: Case report and literature review

Lustosa, Rômulo Maciel / Iwaki, Lilian Cristina Vessoni / Tolentino, Elen de Souza / Chicarelli da Silva, Mariliani / de Oliveira Lazarin, Rafael / Iwaki Filho, Liogi

Pages: 869-874
PMID: 25191673
DOI: 10.3290/j.qi.a32639

Recombinant human bone morphogenetic protein-type 2 (rhBMP-2) is used in oral and maxillofacial procedures due to its endochondral bone formation capacity, and this is also the reason for its use off-label in jaw reconstruction. This study reports a case of an extensive central giant cell lesion along the mandibular body and symphysis. Treatment consisted of enucleation and curettage followed by off-label use of rhBMP-2 associated with bovine bone xenograft. The literature concerning mandibular reconstruction using rhBMP-2 was also reviewed.

Keywords: bone graft, bone morphogenetic protein-type 2, mandibular reconstruction, xenograft

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