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Quintessence Publishing: Journals: QI
Quintessence International

Edited by Eli Eliav

ISSN 0033-6572 (print) • ISSN 1936-7163 (online)

March 2013
Volume 44 , Issue 3

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Treatment of infrabony periodontal defects using a resorbable biopolymer of hyaluronic acid: A randomized clinical trial

Briguglio, Francesco / Briguglio, Enrico / Briguglio, Roberto / Cafiero, Carlo / Isola, Gaetano

Pages: 231-240
PMID: 23444204
DOI: 10.3290/j.qi.a29054

Objective: This randomized clinical study examined the use of hyaluronic acid to treat infrabony periodontal defects over a period of 24 months. Method and Materials: Forty subjects with a two-wall infrabony defect (probing depth [PD] >= 7 mm; clinical attachment level [CAL] >= 7 mm) were selected. The defects were randomly divided into two groups: sites treated with hyaluronic acid (test group) and those treated with open flap debridement (control group). Results: The 12- and 24-month evaluations were based on clinical and radiographic parameters. The primary outcome variable was CAL. Test defects shows a mean CAL gain of 1.9 1.8 mm, while the control defects yielded a significantly lower gain of 1.1 0.7 mm. PD reduction was also significantly higher in the test group (1.6 1.2 mm) than in the control group (0.8 0.5 mm). Frequency distribution analysis of the study outcomes indicated that hyaluronic acid increased the predictability of clinically significant results (CAL gains >= 2 mm and PD reduction >= 2 mm) in the test group compared with the controls. Conclusions: The treatment of infrabony defects with hyaluronic acid offered an additional benefit in terms of CAL gain, PD reduction, and predictability compared to treatment with open flap debridement. Keywords: hyaluronic acid, infrabony periodontal defect, periodontal disease, periodontal regeneration, randomized clinical trial

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