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Quintessence Publishing: Journals: QI
Quintessence International

Edited by Eli Eliav

ISSN 0033-6572 (print) • ISSN 1936-7163 (online)

September 2012
Volume 43 , Issue 8

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Genotoxicity of digital panoramic radiography on oral epithelial tissues

Soheyl Sheikh, MDS/Shambulingappa Pallagatti, MDS/Harshaminder Grewal, MDS/Aman Kalucha, MDS/Harkamal Kaur, MDS

Pages: 719-725
PMID: 23034425

Objective: To evaluate the genotoxic effects of x-rays on gingival and buccal epithelial cells during panoramic dental radiography using the micronucleus test. Method and Materials: Eighty otherwise healthy subjects who required a diagnostic panoramic radiograph and met the selection criteria were included in the study. Epithelial cells were obtained from the maxillary anterior gingiva and buccal mucosa by gentle scraping with a wooden spatula immediately before exposure and again 10 days after exposure. Cytologic preparations were made according to the Papanicolaou staining method and analyzed under a light microscope for micronucleus count. Results: The mean SD micronucleus count of gingival epithelial cells was 1.08 0.76 before radiographic exposure and 1.6 0.93 after exposure. This increase was statistically significant (P < .05). Similarly, there was an increase in the postexposure micronucleus count in the buccal mucosa, but this increase was not significant (P > .05). A significant correlation was observed between the age of subjects and micronucleus count, although no such correlation was found between sex and micronucleus count. Conclusion: Although radiation-related effects from panoramic radiography were reduced compared with full-mouth intraoral periapical radiographs or radiotherapy, the results of this study show that genotoxic effects do take place. Thus, radiographs should be taken with adequate protection measures and only when the potential benefit outweighs the potential risk. (Quintessence Int 2012;43:719725)

Key words: DNA damage, micronucleus test, panoramic radiography, radiation hazard

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