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Quintessence Publishing: Journals: QI
Quintessence International

Edited by Eli Eliav

ISSN 0033-6572 (print) • ISSN 1936-7163 (online)

February 2012
Volume 43 , Issue 2

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Intraoral granular cell tumors: Clinicopathologic and immunohistochemical study

Valéria Souza Freitas, DDS, MSc/Jean Nunes dos Santos, DDS, MSc, PhD/Márcio Campos Oliveira, DDS, MSc, PhD/Pedro Paulo de Andrade Santos, DDS, MSc/Roseana de Almeida Freitas, DDS, MSc, PhD/Lélia Batista de Souza, DDS, MSc, PhD

Pages: 135–142
PMID: 22257875

Objective: To describe a case series of intraoral granular cell tumors in terms of clinical, histologic, and immunohistochemical features. Method and Materials: Nine cases of intraoral granular cell tumors were described in terms of clinical features (patient sex and age, anatomical location, size, type, time to clinical progression, and lesion treatment), histologic features (necrosis, spindling, vesicular nuclei with large nucleoli, increased mitotic activity, high nuclear to cytoplasmic ratio, and pleomorphism) and immunohistochemical features using S-100, CD68, neurofilament protein, desmin, and galectin-1. Results: Studied patients were mostly women with a mean age of 32 years. Lesions arose as solitary nodules on the tongue, with size ranging from 0.1 to 3.0 cm. Mean time to evolution was 21.83 months. All cases were treated by surgical excision. Two cases were classified as atypical and seven as benign. All cases presented immunoreactivity for S-100, CD68, and galectin-1, and there was no reactivity for desmin and neurofilament protein. Conclusion: General practitioners should consider granular cell tumors during the differential diagnosis of nodular lesions on the tongue. Results suggest that histologic criteria may be used to distinguish between benign and atypical intraoral granular cell tumors. Finally, analysis of the clinical profile and the use of immunohistochemical markers may facilitate diagnosis and clarify the histogenesis of these lesions. (Quintessence Int 2012;43:135–142)

Key words: Abrikossoff tumor, granular cell tumor, histopathology, immunohistochemistry

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