Follow Us      

LOGIN
 
Share Page:
Back

Volume 31 , Issue 4
July/August 2011

Pages 365 (e17-e28)


Evaluation of Gene Expression in MG63 Human Osteoblastlike Cells Exposed to Tantalum Powder by Microarray Technology


Vincenzo Sollazzo, MD/Furio Pezzetti, PhD/Leo Massari, MD/Annalisa Palmieri, PhD/Giorgio Brunelli, MD/Ilaria Zollino, MD/Alessandra Lucchese, DDS/Gaetano Caruso, MD/Francesco Carinci, MD8


PMID: 21837296
DOI: 10.11607/prd.00.0996

Conventional orthopedic implants are composed from titanium. To improve some characteristics (ie, volumetric porosity, modulus of elasticity, frictional modulus), a new porous tantalum biomaterial has been developed and its biocompatibility reported. By using DNA microarrays containing 20,000 genes, several genes whose expression were significantly up- or down-regulated were identified in an osteoblastlike cell line (MG63) cultured with tantalum powder (TP). The differentially expressed genes cover a broad range of functional activities: signaling transduction; transcription; cell cycle regulation, proliferation, and apoptosis; and cytoskeleton formation. To the authors’ knowledge, the data reported represent the first genetic portrait of TP. (Int J Periodontics Restorative Dent 2011;31:e17–e28.)


Full Text PDF File | Order Article

 

 
Get Adobe Reader
Adobe Acrobat Reader is required to view PDF files. This is a free program available from the Adobe web site.
Follow the download directions on the Adobe web site to get your copy of Adobe Acrobat Reader.

 

© 2014 Quintessence Publishing Co, Inc

PRD Home
Current Issue
Ahead of Print
Archive
Author Guidelines
About
Accepted Manuscripts
Submission Form
Submit
Reprints
Permission
Advertising
Quintessence Home
Terms of Use
Privacy Policy
About Us
Contact Us
Help