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Volume 31 , Issue 4
July/August 2011

Pages 365 (e17-e28)

Evaluation of Gene Expression in MG63 Human Osteoblastlike Cells Exposed to Tantalum Powder by Microarray Technology

Vincenzo Sollazzo, MD/Furio Pezzetti, PhD/Leo Massari, MD/Annalisa Palmieri, PhD/Giorgio Brunelli, MD/Ilaria Zollino, MD/Alessandra Lucchese, DDS/Gaetano Caruso, MD/Francesco Carinci, MD8

PMID: 21837296
DOI: 10.11607/prd.00.0996

Conventional orthopedic implants are composed from titanium. To improve some characteristics (ie, volumetric porosity, modulus of elasticity, frictional modulus), a new porous tantalum biomaterial has been developed and its biocompatibility reported. By using DNA microarrays containing 20,000 genes, several genes whose expression were significantly up- or down-regulated were identified in an osteoblastlike cell line (MG63) cultured with tantalum powder (TP). The differentially expressed genes cover a broad range of functional activities: signaling transduction; transcription; cell cycle regulation, proliferation, and apoptosis; and cytoskeleton formation. To the authors’ knowledge, the data reported represent the first genetic portrait of TP. (Int J Periodontics Restorative Dent 2011;31:e17–e28.)

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