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Volume 31 , Issue 3
May/June 2011

Pages 247-253


Coverage of Gingival Recession Defects Using Guided Tissue Regeneration With and Without Adjunctive Enamel Matrix Derivative in a Dog Model

Takahisa Fujita, DDS/Shigeki Yamamoto, DDS, PhD/Mikio Ota, DDS, PhD/Yoshihiro Shibukawa, DDS, PhD/Satoru Yamada, DDS, PhD


PMID: 21556381
DOI: 10.11607/prd.00.0977

The aim of this study was to clarify the adjunctive effect of enamel matrix derivative (EMD) on expanded polytetrafluoroethylene membrane guided tissue regeneration (GTR)–based root coverage by creating gingival recessions in beagle dogs. Recessions were treated with GTR + EMD, GTR alone, or neither GTR nor EMD (control). The control group was characterized by long junctional epithelium and little bone formation. The GTR + EMD group showed a statistically significant increase (P < .01) in new bone and cementum formation compared with the GTR group. The results of the present investigation suggest that the adjunctive use of EMD with GTR promotes formation of new bone and cementum without root resorption in recession-type defects in dogs. (Int J Periodontics Restorative Dent 2011;31:247–253.)


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