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Volume 30 , Issue 2
March/April 2010

Pages 173-179


Comparison of Clinical Outcomes Following Guided Tissue Regeneration Treatment with a Polylactic Acid Barrier or a Collagen Membrane

Shih-Yun Wu, DDS/Yen-Ting Chen, DDS, MS/Chi-Wei Chen, DDS, MS/Lin-Yang Chi, DDS, PhD/Nai-Ying Hsu, DDS/Shan-Ling Hung, PhD/Li-Jane Ling, DDS, MS


PMID: 20228976
DOI: 10.11607/prd.00.0914

This prospective, randomized, controlled clinical trial compared the clinical outcomes for a polylactic acid barrier versus a collagen membrane in conjunction with guided tissue regeneration (GTR). Thirty patients with chronic periodontitis and at least one intrabony defect of a minimum 4 mm were enrolled. Following full-mouth scaling, GTR using a collagen membrane or a polylactic acid barrier was performed at one site in each patient. At 1 week before and 6 months after surgery, probing pocket depth (PPD), clinical attachment level (CAL), marginal tissue recession, and bone fill were assessed. A significant reduction in PPD (2.50 1.35 mm for the polylactic acid barrier and 2.60 1.08 mm for the collagen membrane) was obtained, in addition to gains in CAL (2.40 1.17 mm for the polylactic acid barrier and 2.60 1.26 mm for the collagen membrane) and bone fill (0.33 1.89 mm for polylactic acid barrier and 2.57 1.64 mm for collagen membrane), for each group compared to baseline. Significantly, the results from 6 months after surgery showed that there was greater bone fill when the collagen membrane was used compared to the polylactic acid barrier. (Int J Periodontics Restorative Dent 2010;30:173179.)


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