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Volume 20 , Issue 5
September/October 2000

Pages 487-497

The Use of Autologous Growth Factors in Periodontal Surgical Therapy: Platelet Gel Biotechnology--Case Reports

Juan J. de Obarrio, DDS, MS/Jose I. Ara˙z-Dutari, DDS/Thaddeus M. Chamberlain, DDS/Aracelly Croston, MT

PMID: 11203586
DOI: 10.11607/prd.00.0378

The role of polypeptide growth factors in periodontal regeneration has been documented through animal and human studies. Human platelets contain platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-beta) in their alpha granules. PDGF has been shown to play a role in periodontal regeneration. It has been demonstrated that TGF-beta has a very potent effect on cells associated with bone. The case reports presented demonstrate a new biotechnology in which platelet gel is used in combination with demineralized freeze-dried bone allografts for the treatment of periodontal osseous defects. The treated teeth presented with severe bone loss and a guarded prognosis. Platelet gel biotechnology was used as a novel treatment modality. A significant reduction in probing depths was noted, and radiographically significant amounts of new bone were visible as early as 2 months postoperative. Results up to 2 years postoperative are presented.

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