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   Offical Journal of The Academy of Osseointegration

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Volume 29 , Issue 2
March/April 2009

Pages 129-139

Human Histologic Evaluation of Mineralized Collagen Bone Substitute and Recombinant Platelet-Derived Growth Factor-BB to Create Bone for Implant Placement in Extraction Socket Defects at 4 and 6 Months: A Case Series

Marc L. Nevins/Marcelo Camelo/Peter Schupbach/David M. Kim/Joao Marcelo Borges Camelo/Myron Nevins

PMID: 19408475
DOI: 10.11607/prd.00.0854

The objective of this pilot study was to assess whether mineralized collagen bone substitute (MCBS) combined with recombinant human platelet-derived growth factor-BB (0.3 mg/mL) would generate adequate viable bone in buccal wall extraction defects to accommodate implant placement. The primary outcome variable was bone quality, as measured by microcomputed tomography and histologic evaluation. This was successfully accomplished in all eight specimens obtained from seven patients. The secondary outcome variables were bone quality and quantity as observed clinically, radiographically, and by the primary stability of implants at the time of placement. Soft tissue healing was excellent, and there were no unanticipated adverse events. Robust bone formation accompanied by MCBS resorption was evident in all 4- and 6-month specimens. This was accomplished without barrier membranes. (Int J Periodontics Restorative Dent 2009;29:129139.)

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