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Volume 28 , Issue 5
September/October 2008

Pages 461-467


Root Coverage with Cultured Gingival Dermal Substitute Composed of Gingival Fibroblasts and Matrix: A Case Series

Masashi Murata, PhD, DDS/Kazuhiro Okuda, PhD, DDS/Manabu Momose, PhD, DDS/Kentarou Kubo, PhD/Yoshimitsu Kuroyanagi, PhD/Larry F. Wolff, PhD, DDS/Hiromasa Yoshie, PhD, DDS


PMID: 18990997
DOI: 10.11607/prd.00.0824

Cultured gingival dermal substitute (CGDS), composed of gingival fibroblasts and matrix and fabricated using tissue-engineering techniques, has been used for root coverage procedures. Fourteen sites from four patients with ≥ 2 mm of Miller Class I or II facial gingival tissue recession were treated. The autologous CGDS sheet, prepared prior to surgical treatment, was grafted over the teeth with gingival recession and then covered with a coronally positioned flap. Vertical and horizontal recession was measured at baseline (prior to the surgical procedure) and 13 to 40 weeks (average: 30.7 9.6 weeks) after surgery. The average vertical and horizontal root coverage after surgery was 79.1% 25.7% and 75.2% 31.4%, respectively. Moreover, there was a significant increase of keratinized and attached gingival tissue at the final clinical evaluation compared with preoperative measurements (P < .05). These results demonstrate CGDS as a promising grafting material for use with root coverage procedures in periodontal therapy. (Int J Periodontics Restorative Dent 2008;28:461467.)


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