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Volume 28 , Issue 3
May/June 2008

Pages 239-243

Three-Dimensional Alveolar Bone Reconstruction with a Combination of Recombinant Human Platelet-Derived Growth Factor BB and Guided Bone Regeneration: A Case Report

Massimo Simion, MD, DDS/Isabella Rocchietta, DDS/Maurizio Monforte, MD, DDS/Emilio Maschera, MD, DDS

PMID: 18605599
DOI: 10.11607/prd.00.0805

A report of a patient who presented with severe disfigurement of the maxillary left lateral incisor and canine area following oncologic surgery is presented. The bone defect extended 20 mm from the cervical line of adjacent teeth up to and including the nasal cavity. Treatment was performed with a 1:1 ratio of autogenous bone graft (harvested from the retromolar region) and deproteinized bovine bone particles. The composite graft was hydrolyzed with recombinant human platelet-derived growth factor BB and covered with a titanium-reinforced nonresorbable membrane. Second-stage surgery was performed at 6 months, at which point the membrane was removed and two titanium dental implants were successfully placed. The elapsed time from initial surgery to definitive prosthesis placement was 14 months. (Int J Periodontics Restorative Dent 2008;28:239243.)

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