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Volume 27 , Issue 5
September/October 2007

Pages 421-427

Clinical Results Using Recombinant Human Platelet-Derived Growth Factor and Mineralized Freeze-Dried Bone Allograft in Periodontal Defects

Myron Nevins, DDS / James Hanratty, DDS / Samuel E. Lynch, DMD, DMS

PMID: 17990438
DOI: 10.11607/prd.00.0764

Human studies have demonstrated the safety and effectiveness of highly purified recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in combination with osteoconductive matrices for the treatment of moderate to severe periodontal intrabony defects. These study results, together with binding and release characteristics for rhPDGF-BB with different matrices, provide clear evidence that demineralized freeze-dried bone allograft and b-tricalcium phosphate (b-TCP) each can be combined with rhPDGF-BB to promote significant improvements in clinical, radiographic, and histologic parameters. The purpose of the current case series was to determine the clinical and radiographic regenerative potential of rhPDGF-BB–enhanced mineralized freeze-dried bone allograft (FDBA) for the treatment of severe periodontal intrabony defects. Clinical reentry and radio-graphs at up to 11 months showed complete bone fill in these challenging cases, indicating that rhPDGF combined with FDBA provides excellent clinical results. (Int J Periodontics Restorative Dent 2007; 27:421–427.)

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