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   Offical Journal of The Academy of Osseointegration

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Volume 39 , Issue 5
September/October 2019

Pages 709718

Strategic Use of Ultrasonic Frequencies for Targeted Bone Biomodification Following Piezoelectric Bone Surgery in Rats. Part I: Early Phase

Taisuke Ohira, DDS, PhD/Alessia De Vit, DDS, MSD/Serge Dibart, DMD

PMID: 31449583
DOI: 10.11607/prd.4215

Piezocision can set in motion a cascade of physiologic events that lead to accelerated orthodontics, but do all ultrasonic frequencies generate the same effects on bone? Two different Piezotome modulation frequencies (10 and 30 Hz) were tested on the rat maxilla. The animals were sacrificed at days 1, 3, 7, 14, 28, and 70, and MRI, histologic, and biochemical analyses were performed. The results indicated that at 30 Hz, the demineralization process started at day 1 and peaked at day 7, and was initiated by osteocyte apoptosis. The process was different in the two groups, with bone demineralization increasing significantly in the 30-Hz group compared to the 10-Hz group (P < .05). These results could indicate that bone biomodification is frequency-dependent.

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