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Volume 25 , Issue 3
May/June 2005

Pages 265275

Attachment of Periodontal Ligament Cells onto Various Antibiotics-Loaded GTR Membranes

Shan-Ling Hung, PhD/Yi-Wen Lin, MS/Yen-Ting Chen, DDS, MS/Li-Jane Ling, DDS, MS

PMID: 16001739
DOI: 10.11607/prd.00.0638

This study compared the natures of various guided tissue regeneration (GTR) membranes impregnated with amoxicillin or tetracycline. Whether the antibiotics-loaded membranes enhance the attachment of the periodontal ligament cells in the presence of oral pathogens was further analyzed. S mutans and A actinomycetemcomitans diminished the attachment of periodontal ligament cells onto the membranes as evaluated by SEM analysis. These bacterial effects on cellular attachment could be reversed using the antibiotics-loaded membranes. The information obtained in this study is valuable for the future application of antibiotics-loaded membranes during GTR therapy. (Int J Periodontics Restorative Dent 2005;25:265275.)

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