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Volume 39 , Issue 3
May/June 2019

Pages 371379


Bone Tissue Responses to Zirconia Implants Modified by Biomimetic Coating Incorporated with BMP-2

Fei Teng, MDS, PhD/Yuanna Zheng, DDS, PhD/Gang Wu, PhD/Bart Beekmans, DDS/Daniel Wismeijer, PhD/Xingnan Lin, MDS, PhD/Yuelian Liu, PhD


PMID: 30986287
DOI: 10.11607/prd.3980

This study aimed to histologically investigate the bone tissue response to zirconia implants functionalized with a biomimetic calcium phosphate (CaP) coating incorporated with bone morphogenetic protein-2 (BMP-2). Zirconia implants coated with biomimetic CaP were prepared with and without BMP-2. Untreated zirconia implants served as a control. These three groups of implants were placed randomly in the mandibles of six beagle dogs (n = 6). Three months later, samples were harvested for histomorphometric analysis. The present study showed that the application of a biomimetic CaP coating incorporated with BMP-2 enhanced the peri-implant osteogenesis for zirconia implants.


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