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Volume 35 , Issue 3
May/June 2015

Pages 387–393


A Randomized, Crossover Trial to Evaluate the Effect of Two Mouthrinses on Plaque Regrowth in the Absence of Brushing

Marc Nehme, DDS, MSc/Katy Malpass, BSc (Hons), PhD/Andrew Butler, BSc, CStat/Stephen Mason, BSc, MSc, PhD, MRSC (CChem)/Carl J. Kleber, MSD, PhD/Jeffery L. Milleman, DDS, MPA/Kimberly R. Milleman, RDH, BSEd, MS


PMID: 25909526
DOI: 10.11607/prd.2266

This study assessed the effects on plaque in the absence of brushing of two twice-daily mouthrinses, one with an enzymatic-based formulation (Biotène) and one with an antimicrobial chlorhexidine-based formulation (Peridex), and sterile water. Plaque levels were assessed in 23 participants using a 4-day, nonbrushing plaque regrowth model after twice-daily rinsing with sterile water (negative control), the enzyme-based mouthrinse, or the chlorhexidine-based mouthrinse (positive control). Peridex showed significantly greater prevention of plaque regrowth when compared with water and the enzyme-based Biotène mouthrinse. After 4 days, the enzyme-based mouthrinse was associated with a small but nonsignificant reduction in plaque regrowth compared with water. This study confirmed that Peridex is effective at prevention of plaque regrowth. Twice-daily rinsing with a Biotène formula that contained enzymes showed a small but nonsignificant trend toward prevention of plaque regrowth versus rinsing with water.


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