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Volume 33 , Issue 2
March/April 2013

Pages e72e78

Effects of PDGF-BB and OP-1 on Mesenchymal Stem Cells in a Porous Mineral Block

Keisuke Wada, DMD, PhD, DMSc/Victor H. Gerbaudo, PhD, MSHCA/Myron Spector, PhD

PMID: 23484183
DOI: 10.11607/prd.1670

The aim of this study was to evaluate the effects of an osteogenic medium supplemented with platelet-derived growth factor (PDGF) BB and osteogenic protein (OP) 1 on the proliferation and differentiation of mesenchymal stem cells (MSCs) in an anorganic bovine cancellous bone scaffold. At day 7, there was a statistically significant increase in the number of cells in the scaffolds in the group treated with the medium supplemented with both PDGF-BB and OP-1 when compared with the control groups. The highest alkaline phosphate levels, at 14 and 21 days, were recorded for the samples in medium supplemented with OP-1 alone reflecting osteogenic differentiation. The results commend OP-1, as well as PDGF-BB, for incorporation into porous mineral scaffolds for vertical ridge augmentation. (Int J Periodontics Restorative Dent 2013;33:e72e78. doi: 10.11607/prd.1670)

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