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   Offical Journal of The Academy of Osseointegration

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Volume 23 , Issue 4
July/August 2003

Pages 371–379

Use of a Resorbable Hydroxyapatite–Collagen Chondroitin Sulfate Material on Immediate Postextraction Sites: A Clinical and Histologic Study

Alberto Rebaudi, MD, DDS/Piero Silvestrini, MD, DDS, PhD/Paolo Trisi, DDS, PhD

PMID: 12956481
DOI: 10.11607/prd.00.0535

This study looked at a bone-substitute biomaterial (Biostite) used to fill bone defects around immediate implants in humans. Ninety-six peri-implant bone defects were treated without the use of membranes, comparing two groups: group A = filling the defect with Biostite, and group B = no defect fill. After 4 to 6 months of healing, group A revealed higher percentages of implants covered by new, bone-like tissue (67% in group A, 34% in group B). Endochondral osteogenesis was demonstrated histologically in the regenerated tissues in alveolar sites treated, allowing the hypothesis of bone induction from the filling material used. (Int J Periodontics Restorative Dent 2003;23:371–379.)

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