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Volume 32 , Issue 2
April 2012

Pages 195-202

Impact of Recombinant Platelet-Derived Growth Factor BB on Bone Regeneration: A Study in Rabbits

Daniel S. Thoma, Dr Med Dent/Ronald E. Jung, PD Dr Med Dent/Patrick Hänseler, MSc ETH/Christoph H.F. Hämmerle, Prof Dr Med Dent/David L. Cochran, DDS, PhD/Franz E. Weber, PD PhD

PMID: 22292149
DOI: 10.11607/prd.00.1056

The aim of this study was to test whether recombinant human platelet-derived growth factor BB (rhPDGF-BB) enhances bone regeneration in combination with β-tricalcium phosphate (β-TCP) granules or deproteinized bovine bone mineral (DBBM) compared to empty defects and β-TCP granules alone. Four titanium cylinders were placed on the external cortical plates of seven rabbits’ calvaria and randomly allocated to one of four groups: (1) empty, (2) β-TCP, (3) β-TCP + rhPDGF-BB, and (4) DBBM + rhPDGF-BB. The mean area of bone regeneration was 13.9% ± 8.4% (empty), 24.0% ± 14.8% (β-TCP), 37.1% ± 8.9% (β-TCP + rhPDGF-BB), and 64.4% ± 5.4% (DBBM + rhPDGF-BB), with the greatest bone regeneration noted for DBBM + rhPDGF-BB (P < .01). The fraction of bone substitute material varied between 48.3% ± 9.3% (DBBM + rhPDGF-BB), 53.1% ± 10.6% (β-TCP + rhPDGF-BB), and 58.0% ± 14.8% (β-TCP). rhPDGF-BB combined with DBBM showed the greatest potential to enhance bone regeneration. (Int J Periodontics Restorative Dent 2012;32:195-202.)

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