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Volume 12 , Issue 3
May/June 1997
Pages 403-411

A New Animal Model for Maxillary Sinus Floor Augmentation: Evaluation Parameters

Kirker-Head/Nevins/Palmer/Nevins/Schelling

PMID: 9197107

This study describes a novel animal model of the maxillary sinus floor augmentation procedure used to assess bone formation during 12 weeks in response to a recombinant human bone morphogenetic protein-2 (rhBMP-2)/absorbable collagen sponse (ACS) sinus implant. A buffer-ACS implant was used as a control. Animal response was monitored using computerized tomography and physical, hematologic, gross pathologic, and histologic evaluations. The rhBMP-2/ACS implants maintained a relatively constant size postsurgery and showed a time-dependent increase in mineralization. The buffer/ACS control implants failed to mineralize and were resorbed by 4 weeks. The model served effectively and without complication. Results indicate rhBMP-2/ACS implants deserve consideration as alternatives to traditional grafting procedures.

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