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Volume 26 , Issue 3
May/June 2011

Pages 561570

Microcomputed Tomographic and Histologic Analysis of Anorganic Bone Matrix Coupled with Cell-Binding Peptide Suspended in Sodium Hyaluronate Carrier After Sinus Augmentation: A Clinical Study

Hany Emam, BDS, MS/Galal Beheiri, BDS, MS, PhD/Mohammed Elsalanty, MD, PhD/Mohamed Sharawy, BDS, MS, PhD

PMID: 21691603

Purpose: Anorganic bovine hydroxyapatite matrix (ABM), when coupled with synthetic cell-binding peptide (P15), mimics the cell-binding region of type 1 collagen and is commercially available suspended in a sodium hyaluronate carrier. The aim of the present study, therefore, was to test the efficacy of ABM/P-15 Putty (DENTSPLY Friadent CeraMed) as a sole graft material for sinus augmentation in patients with severely resorbed posterior maxillae. Materials and Methods: Sinus augmentation was performed in 10 patients using ABM/P-15 Putty and two provisional dental implants (3.0 mm in diameter). The graft and implants were placed simultaneously with the aid of a surgical stent. After 8 or 16 weeks, the implants were removed using a 4.25-mm trephine bur; this was followed by immediate placement of wider-diameter (5.5-mm) implants. All 20 implants were scanned by microcomputed tomography to determine bone mineral density (BMD), percent bone volume (PBV), and percent bone contact (PBC). Results: There was a significant increase in the BMD of bone around the implants at 8 weeks and 16 weeks compared to native residual (control) bone. There was no significant difference in PBV or PBC between 8 weeks and 16 weeks. The average increase in bone height at 16 weeks was 9.63 1 mm. Microcomputed tomographic images and histologic sections showed dense graft particles surrounded by vital trabecular bone. Conclusion: BMD increases as early as 8 weeks and does not show an additional increase after 16 weeks. PepGen P-15 Putty was found to be a promising osteoconductive graft for sinus augmentation, supporting immediate placement of implants. Int J Oral Maxillofac Implants 2011;26:561570

Key words: anorganic bone matrix, cell-binding peptide, microcomputed tomography, sinus augmentation

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