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Volume 26 , Issue 2
March/April 2011

Pages 245250

The Effect of Hydroxyapatite-Coated Titanium Fiber Web on Human Osteoblast Functional Activity

Makoto Hirota, DDS, PhD/Tohru Hayakawa, PhD/Akihiro Ametani, PhD/Yoshinori Kuboki, PhD/Mitsunobu Sato, PhD/Iwai Tohnai, DDS, PhD

PMID: 21483876

Purpose: The aim of this study was to evaluate human osteoblast activity on thin hydroxyapatite (HA)-coated three-dimensional scaffolds made of titanium fiber web. Materials and Methods: A thin HA film was coated on a titanium fiber web by the molecular precursor method. Human osteoblasts were disseminated onto the uncoated and HA-coated titanium fiber web, and osteoblast activity was observed at days 3, 7, 14, and 21 of culture. Results: Proliferation activities of osteoblasts were significantly higher in the uncoated titanium fiber web. Osteoblasts in the uncoated titanium fiber web showed a typical expression pattern, but those in the HA-coated titanium fiber web showed rapid osteocalcin expression and calcification at an early stage of culture. Moreover, osteocalcin expression per osteoblast was significantly higher in the HA-coated group. Conclusion: These results suggest that HA coating with the molecular precursor method accelerated osteoblast functional activity. Int J Oral Maxillofac Implants 2011;26:245250

Key words: functional activity, hydroxyapatite coating, molecular precursor method, osteoblast, titanium fiber web

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