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Volume 26 , Issue 2
March/April 2011
Pages 237–244

Osteoblastlike Cell Adhesion on Titanium Surfaces Modified by Plasma Nitriding

José Sandro Pereira da Silva, DDS, PhD/Sandro Campos Amico, PhD/Almir Olegário Neves Rodrigues, DDS/Carlos Augusto Galvão Barboza, DDS, PhD/Clodomiro Alves Jr, PhD/Alberto Tesconi Croci, MD

PMID: 21483875

Purpose: The aim of this study was to evaluate the characteristics of various titanium surfaces modified by cold plasma nitriding in terms of adhesion and proliferation of rat osteoblastlike cells. Materials and Methods: Samples of grade 2 titanium were subjected to three different surface modification processes: polishing, nitriding by plasma direct current, and nitriding by cathodic cage discharge. To evaluate the effect of the surface treatment on the cellular response, the adhesion and proliferation of osteoblastlike cells (MC3T3) were quantified and the results were analyzed by Kruskal-Wallis and Friedman statistical tests. Cellular morphology was observed by scanning electron microscopy. Results: There was more MC3T3 cell attachment on the rougher surfaces produced by cathodic cage discharge compared with polished samples (P < .05). Conclusions: Plasma nitriding improves titanium surface roughness and wettability, leading to osteoblastlike cell adhesion. Int J Oral Maxillofac Implants 2011;26:237–244

Key words: cell growth, osteoblast adhesion, plasma nitriding, titanium

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