Share Page:

Volume 25 , Issue 6
November/December 2010

Pages 12461252

The Use of Recombinant Human Bone Morphogenetic Protein-2 for the Repair of Extraction Socket Defects: A Technical Modification and Case Series Report

Craig M. Misch, DDS, MDS

PMID: 21197504

Purpose: The purpose of this case series was to evaluate the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in an absorbable collagen sponge (ACS) carrier for the repair of significant bone defects following tooth removal. The surgical technique was modified because primary closure was not obtained over the grafted sockets. Materials and Methods: The present series included 10 consecutively treated patients with failed endodontically treated maxillary central incisors. Computed tomographic scans were obtained preoperatively. The extraction sockets all had > 50% buccal bone loss. The sockets were grafted with rhBMP-2/ACS and a small amount of bone substitute. Dental implants were inserted after 4 to 6 months of healing. Results: Healing of the grafted sockets was uneventful. Dental implants were placed in all grafted sites without the need for further bone augmentation. A comparison of preoperative and postgrafting computed tomographic scans found a slight loss in alveolar width at the crest of 1.07 mm. Connective tissue grafts were placed in five patients. All 10 implants integrated well and were restored with single crowns. Conclusions: The use of rhBMP-2/ACS was effective in repairing osseous defects prior to implant placement. The lack of primary closure over the graft did not appear to complicate healing or compromise bone growth. This modification simplifies the technique and may reduce postoperative morbidity caused by flap manipulation. Int J Oral Maxillofac Implants 2010;25:12461252

Key words: bone graft, dental implants, extraction socket, recombinant human bone morphogenetic protein-2

Full Text PDF File | Order Article


Get Adobe Reader
Adobe Acrobat Reader is required to view PDF files. This is a free program available from the Adobe web site.
Follow the download directions on the Adobe web site to get your copy of Adobe Acrobat Reader.


© 2018 Quintessence Publishing Co, Inc JOMI Home
Current Issue
Ahead of Print
Author Guidelines
Submission Form
Quintessence Home
Terms of Use
Privacy Policy
About Us
Contact Us