LOGIN
 
Share Page:
Back

Volume 25 , Issue 5
September/October 2010

Pages 888892


Use of the Molecular Precursor Method to Facilitate Thin Hydroxyapatite Coating of Titanium Fiber Web Scaffold and Enhance Bone Formation: An Experimental Study in Rat Cranial Bone Defects

Makoto Hirota, DDS, PhD/Tohru Hayakawa, PhD/Akihiro Ametani, PhD/Yuka Monden, MD/Yasuharu Noishiki, MD, PhD/Iwai Tohnai, DDS, PhD


PMID: 20862401

Purpose: This study evaluated the bone-regeneration properties of titanium fiber web (TW) that had been coated with a thin hydroxyapatite (HA) layer using the molecular precursor method. Materials and Methods: TW disks with or without the thin HA coating were implanted into rat cranial bone defects. The rats were sacrificed after 3 or 6 weeks. New bone formation into the TW was evaluated. Results: The porous structure of TW was clearly maintained after the HA coating was applied. In the HA-coated TW group, new woven bone was observed in the majority of the disks after 6 weeks, whereas the control (uncoated TW) group showed limited new bone formation in the interior. The bone formation ratio in the HA-coated group was significantly higher than in the control group (20.6% and 59.1% after 3 and 6 weeks, respectively, versus 2.0% and 15.5%, respectively; P < .05). Conclusions: The molecular precursor method of applying a thin HA coating to TW appeared to effectively enhance new bone formation through maintenance of TW porosity and promotion of osteoconductivity in the TW three-dimensional scaffold. Int J Oral Maxillofac Implants 2010;25:888892

Key words: bone scaffold, hydroxyapatite coating, molecular precursor method, porosity, titanium fiber web


Full Text PDF File | Order Article

 

 
Get Adobe Reader
Adobe Acrobat Reader is required to view PDF files. This is a free program available from the Adobe web site.
Follow the download directions on the Adobe web site to get your copy of Adobe Acrobat Reader.

 

© 2017 Quintessence Publishing Co, Inc JOMI Home
Current Issue
Ahead of Print
Archive
Author Guidelines
About
Accepted Manuscripts
Submission Form
Submit
Reprints
Permission
Advertising
Quintessence Home
Terms of Use
Privacy Policy
About Us
Contact Us
Help