LOGIN
 
Share Page:
Back

Volume 18 , Issue 1
January/February 2003

Pages 15–22


Influence of Platelet-rich Plasma on Osseous Healing of Dental Implants: A Histologic and Histomorphometric Study in Minipigs

Werner Zechner, MD, DDS, Stefan Tangl, MS, Gabor Tepper, MD, DDS, Gabor Fürst, MD, DDS, Thomas Bernhart, MD, DDS, PhD, Prof, Robert Haas, MD, DDS, PhD, Prof, Georg Mailath, MD, DDS, PhD, Prof, Georg Watzek, MD, DDS, PhD, Prof


PMID: 12608664

Purpose: In the present study the time course of local bone formation following the application of PRP during implant placement was evaluated histomorphometrically and histologically. Materials and Methods: The mandibular premolars of 12 adult minipigs were removed surgically and 72 sites were prepared for implant placement. Before the implants (MK III, Replace, and MK III TiUnite) were placed, autogenous PRP (8105 to 10105 platelets/µL) was instilled into the host sites on the left side. The animals were sacrificed at 3, 6, and 12 weeks, and undecalcified ground sections were prepared. Results: The histomorphometric evaluation showed significantly more bone-to-implant contact after topical PRP application in the early healing phase (6 weeks), which varied as a function of the distance from the implant surface (controls = 24.2% versus PRP = 44.21%; P = .013). At 12 weeks, the extent of osteoneogenesis was comparable in the 2 groups (controls = 51.3% versus PRP = 44.2%; P = .251). Statistical analysis revealed no significant interaction between implant surface type and PRP. Discussion: Topical PRP application significantly increased the activity of bone regeneration at implant host sites during early healing. Conclusion: In the present study PRP was found to have a time- and sitedependent effect on peri-implant bone healing. (INT J ORAL MAXILLOFAC IMPLANTS 2003;18:15–22)


Full Text PDF File | Order Article

 

 
Get Adobe Reader
Adobe Acrobat Reader is required to view PDF files. This is a free program available from the Adobe web site.
Follow the download directions on the Adobe web site to get your copy of Adobe Acrobat Reader.

 

© 2014 Quintessence Publishing Co, Inc JOMI Home
Current Issue
Ahead of Print
Archive
Author Guidelines
About
Accepted Manuscripts
Submission Form
Submit
Reprints
Permission
Advertising
Quintessence Home
Terms of Use
Privacy Policy
About Us
Contact Us
Help