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Volume 17 , Issue 4
July/August 2002

Influence of Particle Size of Autogenous Bone Grafts on the Early Stages of Bone Regeneration: A Histologic and Stereologic Study in Rabbit Calvarium

Lars Pallesen, DDS, Søren Schou, DDS, PhD, Merete Aaboe, DDS, PhD, Erik Hjørting-Hansen, DDS, Dr Odont, Anders Nattestad, DDS, PhD, Flemming Melsen, MD, Dr Med

PMID: 12182292

Purpose: The aim of this study was to investigate the influence of particle size of autogenous bone grafts on the early stages of bone regeneration. Materials and Methods: Bicortical skull bone defects were prepared in 15 rabbits (4 in each rabbit). Two defects were filled at random with either small (0.5 to 2 mm3) or large (10 mm3) autogenous bone particles. In addition, 1 defect was left unfilled (control defect). All defects were covered bicortically by expanded polytetrafluoroethylene membranes. The animals were divided randomly into 3 groups and sacrificed after 1, 2, and 4 weeks, respectively. Histologic and stereologic evaluations were performed after the sections were blinded. Results: No significant differences in total vessel surface area could be identified among the 3 groups. The total volume of newly formed bone in defects with small particles was larger and more mature compared to defects with large particles after 2 and 4 weeks. Furthermore, the resorption of small particles was more pronounced after 4 weeks, documenting a higher level of bone substitution compared to large particles. Discussion: The early stages of bone regeneration were influenced by the particle site of autogenous bone grafts. Conclusion: The present study indicated that particles of 0.5 to 2 mm3 in size should be preferred to particles of 10 mm3 in size for bone grafting. (INT J ORAL MAXILLOFAC IMPLANTS 2002;17: 498–506)

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