Share Page:

Volume 17 , Issue 3
May/June 2002

Pages 363–368

Cellular Fibronectin in Failing Dental Implants

Jian Ma, MD, DDS, Timo Sorsa, DDS, PhD, Mauno Könönen, DDS, PhD, Seppo Santavirta, MD, PhD, Ismo Virtanen, MD, PhD, Yrjö Konttinen, MD, PhD

PMID: 12074451

Purpose: Cellular fibronectin staining is decreased in adult periodontitis, which implies elastase-mediated degradation of periodontal tissues. The purpose of this study was to determine whether failing dental implants display similar changes. Materials and Methods: Cellular fibronectin and its integrin receptors were identified by immunohistochemistry and quantified by computerized image analysis. Results: Cellular fibronectin was found in blood vessel walls, epithelial basement membranes, and fibroblasts. Quantitative results of cellular fibronectin staining were as follows: failing dental implants, median 26.5% (Q3–Q1 = 23%); adult periodontitis, median 5.5% (Q3–Q1 = 5.6%); normal controls, median 12.2% (Q3–Q1 = 7.5%). Cellular fibronectin staining was increased around failing dental implants but decreased in adult periodontitis compared to healthy controls. Discussion: The distribution of integrin receptor subunits 4, 5, and 1 of cellular fibronectin was similar in failing dental implants. The pathomechanisms in adult periodontitis and failing dental implants seem to differ. Conclusions: Adult periodontitis is characterized by proteolysis/loss of cellular fibronectin, whereas failing dental implants are characterized by increased cellular fibronectin deposition, probably as a result of titanium-induced local synthesis and relatively modest degradation. (INT J ORAL MAXILLOFAC IMPLANTS 2002;17:363–368)

Full Text PDF File | Order Article


Get Adobe Reader
Adobe Acrobat Reader is required to view PDF files. This is a free program available from the Adobe web site.
Follow the download directions on the Adobe web site to get your copy of Adobe Acrobat Reader.


© 2017 Quintessence Publishing Co, Inc JOMI Home
Current Issue
Ahead of Print
Author Guidelines
Accepted Manuscripts
Submission Form
Quintessence Home
Terms of Use
Privacy Policy
About Us
Contact Us