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Volume 15 , Issue 2
March/April 2000
Pages 175–184

Myelointegration of Titanium Implants: B Lymphopoiesis and Hemopoietic Cell Proliferation in Mouse Bone Marrow Exposed to Titanium Implants

M. Dwayne Rahal, MSc, DMD, PhD, FICD, Danielle Delorme, MSc, Per-Ingvar Brånemark, MD, PhD, Dennis G. Osmond, MB, ChB, DSc, FRSC

PMID: 10795449

Multinucleated giant cells have been observed at interfaces between bone marrow and titanium implants in mouse femurs. This raises concern that macrophage-derived factors might perturb local lymphohemopoiesis, possibly even predisposing to neoplasia in the B lymphocyte lineage. It has been found that an implant-marrow interface with associated giant cells persists for at least 1.5 years. Precursor B cells show early increases in number and proliferative activity. At later intervals, however, they do not differ significantly from controls, and there are no perturbations in spatial localization of either B lineage cells or DNA-synthesizing hemopoietic cells. The results of this investigation in mice demonstrate that, following initial marrow regeneration and fluctuating precursor B cell activity, and despite the presence of giant cells, titanium implants apparently become well-tolerated by directly apposed bone marrow cells in a lasting state of myelointegration. (INT J ORAL MAXILLOFAC IMPLANTS 2000;15:175–184) Key words: B lymphopoiesis, bone marrow, giant cells, hemopoietic microenvironment, titanium implants

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