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Volume 16 , Issue 4
July/August 2001

Pages 563–571

Histologic Evaluation of the Osteoinductive Property of Autogenous Demineralized Dentin Matrix on Surgical Bone Defects in Rabbit Skulls Using Human Amniotic Membrane for Guided Bone Regeneration

Mônica Fernandes Gomes, MD, DDS, Mário James da Silva dos Anjos, MD, DDS, Terezinha de Oliveira Nogueira, MD, DDS, Sérgio Augusto Catanzaro Guimarães, MD, DDS

PMID: 11516004

The aim of this investigation was to evaluate the osteoinductive property of autogenous demineralized dentin matrix (ADDM) on experimental surgical bone defects in the parietal bone of rabbits using the guided bone regeneration (GBR) technique incorporating human amniotic membrane (HAM). Thirty-six rabbits were divided into 2 groups, HAM and ADDM+HAM. It was possible to conclude that HAM did not interfere with bone repair and was resorbed. Slices of ADDM induced direct bone formation and were incorporated by the newly formed bone tissue and remodeled. The bone defects healed faster in the ADDM+HAM group than in the group with HAM only. (INT J ORAL MAXILLOFAC IMPLANTS 2001;16:563–571)
Key words: autogenous demineralized dentin matrix, biologic dressings, bone repair, guided tissue regeneration, human amniotic membrane

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