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Volume 11 , Issue 1
January/February 1996

Pages 55-66

Tissue Reaction and Material Characteristics of Four Bone Substitutes

Simon Storgård Jensen/Merete Aaboe, DDS/Else Marie Pinholt, DDS, MS, Dr Odont/Erik Hjørting-Hansen, DDS, Prof Dr Odont/Flemming Melsen, MD, PhD, Prof Dr Med/I. Eystein Ruyter, Dr Philos, Dr Rer Nat

PMID: 8820123

The aim of the present study was to qualitatively and quantitatively compare the tissue reactions around four different bone substitutes used in orthopedic and craniofacial surgery. Cylinders of two bovine bone substitutes (Endobon and Bio-Oss) and two coral-derived bone substitutes (Pro Osteon 500 and Interpore 500 HA/CC) were implanted into 5-mm bur holes in rabbit tibiae. There was no difference in the amount of newly formed bone around the four biomaterials. Interpore 500 HA/CC resorbed completely, whereas the other three biomaterials did not undergo any detectable biodegradation. Bio-Oss was osseointegrated to a higher degree than the other biomaterials. Material characteristics obtained by diffuse reflectance infrared Fourier transform spectrometry analysis and energy-dispersive spectrometry did not explain the differences in biologic behavior. (INT J ORAL MAXILLOFAC IMPLANTS 1996;11:55–66)

Key words: bone substitute, bovine bone, calcium carbonate, coral, material characteristics, material resorption, porous hydroxyapatite

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