• Submission Form (PDF)
• Author Guidelines (PDF)
• Submit

• Accepted Manuscripts

Back

Volume 10 , Issue 6
November/December 1995
Pages 721-728

Fibronectin and Laminin Enhance Gingival Cell Attachment to Dental Implant Surfaces In Vitro

John W. Dean III, DDS, PhD/Kim C. Culbertson, DDS/Anna M. D’Angelo, BS

PMID: 8530175

The objective of this study was to determine if the biologically active molecules laminin and fibronectin could influence gingival cell attachment to implant surfaces in vitro. Flat squares of the following implant materials were tested: smooth, plasma-sprayed, and hydroxyapatite-coated titanium. The surfaces were coated with equimolar quantities of either laminin, fibronectin, or bovine serum albumin. Fibronectin coating of implant surfaces resulted in two to three times the enhancement of gingival fibroblast binding on all implant surfaces tested (P < .01), with a lesser effect on epithelial cells. Laminin coating resulted in three to four times the enhancement of gingival epithelial cell binding on all implant surfaces tested (P < .01), with a lesser effect on fibroblasts. The two cell types exhibited distinct preferences for the different molecules tested with the surface roughness having some influence. (J Oral Maxillofac Implants 1995;10:721–728)

Key words: attachment, epithelium, fibroblast, fibronectin, implant, laminin

Full Text PDF File | Order Article

 

 

Adobe Acrobat Reader is required to view PDF files. This is a free program available from the Adobe web site.
Follow the download directions on the Adobe web site to get your copy of Adobe Acrobat Reader.