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Volume 9 , Issue 1
January/February 1994
Pages 13-29

Healing Pattern of Bone Regeneration in Membrane-Protected Defects: A Histologic Study in the Canine Mandible

Robert K. Schenk, MD, Prof Dr Med/Daniel Buser, DDS, PD Dr Med Dent/ W. Ross Hardwick,MS/Christer Dahlin, DDS, PhD

PMID: 8150509

In this study, standard and prototype reinforced e-PIFE membranes were used to evaluate the pattern of bone regeneration in membrane protected defects in the mandibles of four dogs. Following a healing period of 2 and 4 months, control sites without membranes exhibited incomplete osseous healing with a persisting defect. Test sites with membranes demonstrated significantly better bone healing, although bone regeneration was not yet completed at 4 months. The histologic evaluation showed that bone regeneration, once activated, progresses in a programmed sequence through a series of maturation steps, which closely resemble the pattern of bone development and growth. (INT J ORAL MAXILLOFAC IMPLANTS 1994;9:13-29.)

Key words: bone defects, bone healing, guided bone regeneration, membranes

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