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Volume 6 , Issue 3
Fall 1991

Pages 294-303

Histological and Clinical Comparisons of Guided Tissue Regeneration on Dehisced Hydroxylapatite-Coated and Titanium Endosseous Implant Surfaces: A Pilot Study

Mark Zablotsky, DDS/Roland Meffert, DDS/Richard Caudill, DDS/Gerald Evans, DDS

PMID: 1667524

Fifty-six endosseous cylindrical implants were placed in dog mandibles 12 weeks after the extraction of all mandibular premolars and first molars. Eight implants, four coated with 50 m of hydroxylapatite (HA) and four grit-blasted and titanium-surfaced, were placed in each dog. Ideal implant placement sites were modified by creating standardized 3 5-mm facial dehiscence defects. Half the dehiscences were treated with a modified expanded polytetrafluoroethylene (PTFE) membrane; the remainder served as controls. After 8 weeks of healing, the animals were sacrificed and measurements made to determine the percentage of dehiscence repair. The HA-coated implants had a mean defect fill of 95.17% and the grit-blasted implants had a percent fill of 82.8% in the guided tissue regeneration (GTR) test group; the control implants demonstrated a mean fill of 55% and 39% in the HA-coated and grit-blasted implants, respectively. Significant differences (P < .05) were noted between both test groups and the titanium control group, and between the HA test and HA control groups. Histologic evaluation showed significantly greater repair associated with HA-coated implants, as well as significant bone loss associated with clinically exposed membranes. It was concluded that within the limitations of this study, guided tissue regeneration is a viable option in treating defects associated with dental implants. (INT J ORAL MAXILLOFAC IMPLANTS 1991;6:294 303.)

Key words: guided tissue regeneration, hydroxylapatite-coated implants, titanium implants

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