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Volume 23 , Issue 5
September/October 2008

Pages 835840

Effects of Prostaglandin E1 Application on Rat Incisal Sockets

Gaichi Iino, DDS/Kenichi Nishimura, DDS/Ken Omura, DDS, PhD/Shohei Kasugai, DDS, PhD

PMID: 19014152

Purpose: Atrophy of the alveolar ridge is a problem in prosthetic and esthetic treatment. In the present study, to examine effects of PGE1 on the alveolar bone after tooth extraction, PGE1 was applied to rat incisal sockets utilizing a slow drug release system using PLGA as the drug carrier. Materials and Methods: Thirty-six male Wistar rats, 10 weeks old, were divided into 3 groups. After all right mandibular incisors were extracted, the sockets were treated in the following manner. The first group was untreated (control group), the second group received a PLGA rod (PLGA group), and the third group was treated with a PLGA rod containing 0.5 mg PGE1 (PGE1 group). Six rats in each group were sacrificed at 4 weeks, and the remaining rats were sacrificed at 8 weeks. For fluorescence labeling, half of the animals were injected with calcein and tetracycline 8 days and 1 day before sacrifice, respectively. After sacrifice, the mandibles were radiologically and histologically examined. Results: In the PGE1 group, the bone volume of the alveolar ridge including the socket was significantly (P < .05) greater than in the control and PLGA groups at 4 and 8 weeks. At 4 weeks in the PGE1 group, the mineral apposition rate and number of osteoclasts were higher than in the other groups, whereas these parameters were similar in all groups at 8 weeks. Conclusion: Based on this animal study, it appears that local application has the potential to preserve and/or augment the alveolar ridge after tooth extraction. Int J Oral Maxillofac Implants 2008;23:835840 Key words: alveolar bone local administration, PLGA, prostaglandin E1, rat, tooth socket

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