Share Page:

Volume 23 , Issue 5
September/October 2008

Bone Metabolic Activity Around Dental Implants Under Loading Observed Using Bone Scintigraphy

Hiroto Sasaki, DDS, PhD/Shigeto Koyama, DDS, PhD/Masayoshi Yokoyama, DDS, PhD/ Keiichiro Yamaguchi, MD/Masatoshi Itoh, MD/Keiichi Sasaki, DDS, PhD

PMID: 19014151

Purpose: The purpose of this study was to determine dynamic changes in bone metabolism around osseointegrated titanium implants under mechanical stress. Materials and Methods: Two titanium implants were inserted parallel to each other in the tibiae of rats and perpendicular to the bone surface with the superior aspect of the implant exposed. Eight weeks after insertion, closed coil springs with 0.5, 1.0, 2.0, and 4.0 N were applied to the exposed superior portion of the implant for 7 weeks to apply a continuous mechanical stress. Bone scintigrams were performed using a gamma camera with a modified high-resolution pinhole collimator. Images were made at 1, 4, 7, 10, 14, 21, 28, 49, and 56 days after insertion and at 3 days and at weekly intervals until 7 weeks after load application. The ratio of the metabolic activity around the implants to that around a reference site (uptake ratio) was established. The Friedman, Steel, and Tukey tests (P < .05) were used to assess statistical significance. Results: In the process of osseointegration, the uptake ratio increased during the first week after implant insertion and then gradually decreased. During the initial 3 weeks the uptake ratio was significantly higher than at 1 day after insertion. In the process of load application, the uptake ratio increased with 2.0- and 4.0-N loads; it was significantly higher until 6 weeks than it had been before load application. Conclusions: Bone metabolism around the implants increases with loading and depends on the magnitude and period of the loading. Int J Oral Maxillofac Implants 2008;23: 827834

Key words: bone metabolism, bone remodeling, bone scintigraphy, mechanical stress osseointegrated titanium implant

Full Text PDF File | Order Article


Get Adobe Reader
Adobe Acrobat Reader is required to view PDF files. This is a free program available from the Adobe web site.
Follow the download directions on the Adobe web site to get your copy of Adobe Acrobat Reader.


© 2017 Quintessence Publishing Co, Inc JOMI Home
Current Issue
Ahead of Print
Author Guidelines
Accepted Manuscripts
Submission Form
Quintessence Home
Terms of Use
Privacy Policy
About Us
Contact Us