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Volume 22 , Issue 4
July/August 2007
Pages 563–568

Influence of Platelet-rich Plasma on Bone Regeneration: A Histomorphometric Study in Rabbit Calvaria

Jesus Torres, DDS, PhD / Isabel Tresguerres, MD, DDS, PhD / Faleh Tamimi, DDS, PhD / Celia Clemente, MD, PhD / Enrique Niembro, MD, PhD / Luis Blanco, MD, DDS, PhD

PMID: 17929516

Purpose: The aim of this study was to evaluate whether local application of platelet-rich plasma (PRP) would induce bone regeneration in cranial defects on rabbits. Materials and Methods: Twelve female New Zealand rabbits were used for this study. Two identical 10-mm-diameter bicortical cranial defects were created in each animal. One of the defects was grafted with PRP, while the contralateral was left unfilled as a negative control. Animals were sacrificed at 2, 4, 6, and 8 weeks after surgery, and biopsy specimens were evaluated histologically and histomorphometrically under light microscopy. Analysis of variance was used for statistical analysis. Results: The histomorphometric evaluation showed more regenerated bone after local administration of PRP at 2 weeks (P > .05), 4 weeks (P < .05), and 6 weeks (P > .05). At week 8, new bone formation was comparable in both groups. Conclusion: In this animal model, local application of PRP in bone defects enhances healing significantly at 4 weeks. Int J Oral Maxillofac Implants 2007; 22:563–568

Key words: bone regeneration, platelet-rich plasma, rabbits

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